The COVID-19 pandemic and its outbreak in Ghana highlighted the multiple roles religious actors can play in crisis management. The pandemic showed that beyond winning souls, shaping morals and preaching the word of God, religious organizations can contribute to policy-decision-making and sensitization to manage life-threatening situations. They exhibited this through collaboration with government and state institutions in planning, sensitizing, and implementing rules and protocols to manage the COVID-19 pandemic in Ghana. Concurrently, the pandemic has demonstrated that religious actors can challenge the authority of governments if their practices contravene established rules and protocols. This policy paper analyzes the specific case of Ghana by drawing future lessons for religious actors, what they can continue to do to further contribute to manage the health crisis, and policy recommendations for government’s action.